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DE-2.29

Submodule 12 genes

MAPK signaling and cytoplasmic protein regulation

This 12-gene module includes MAPK14, ADAM9, RPS6KA3, RANBP9, and LEMD3, with top enriched terms related to MAPK signaling pathway, cytoplasmic protein modification, and kinase activity. Knockdown of SOX17 activates this module, while knockdown of EOMES represses it. No additional repressing TFs are provided.

Key terms: positive regulation of syncytium formation by plasma membrane fusion regulation of syncytium formation by plasma membrane fusion response to lipopolysaccharide response to molecule of bacterial origin Notable genes: MAPK14 ADAM9 RPS6KA3 RANBP9 LEMD3 GAN TAF4 ARHGAP17

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (11)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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