The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. The protein also plays a role in the regulation of antiviral response. Mutations in this are associated with Encephalopathy, acute, infection-induced, herpes-specific 5. [provided by RefSeq, Jul 2020]
Transcription factors with Perturb-seq knockdown data for TRAF3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAF3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAF3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:102,507,117–102,508,097 | 270.0 kb | Distal (>10kb) Multiome | 100 | |
| chr14:102,508,416–102,511,398 | 267.7 kb | Distal (>10kb) Multiome HiCAR | 778 | |
| chr14:102,516,500–102,517,914 | 260.6 kb | Distal (>10kb) Multiome HiCAR | 694 | |
| chr14:102,524,045–102,525,126 | 252.8 kb | Distal (>10kb) Multiome HiCAR | 817 | |
| chr14:102,545,130–102,546,123 | 231.9 kb | Distal (>10kb) Multiome | 458 | |
| chr14:102,554,738–102,555,873 | 222.0 kb | Distal (>10kb) Multiome | 280 | |
| chr14:102,585,306–102,585,775 | 192.0 kb | Distal (>10kb) Multiome | 259 | |
| chr14:102,591,431–102,593,846 | 185.1 kb | Distal (>10kb) Multiome | 895 | |
| chr14:102,773,225–102,773,467 | 4.1 kb | Proximal (<10kb) | 134 | |
| chr14:102,774,956–102,775,164 | 2.4 kb | Proximal (<10kb) | 285 | |
| chr14:102,776,966–102,778,132 | 207 bp | At TSS Multiome | 446 | |
| chr14:102,927,667–102,929,100 | 150.9 kb | Distal (>10kb) Multiome | 328 | |
| chr14:102,929,570–102,930,980 | 152.8 kb | Distal (>10kb) Multiome HiCAR | 178 | |
| chr14:102,954,209–102,955,338 | 177.3 kb | Distal (>10kb) Multiome | 143 | |
| chr14:103,056,337–103,058,497 | 280.1 kb | Distal (>10kb) Multiome | 644 | |
| chr14:103,075,052–103,076,162 | 298.2 kb | Distal (>10kb) Multiome | 656 |
Genomic view of the TRAF3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.