Enables ATP-dependent protein-DNA unloader activity. Involved in several processes, including negative regulation of DNA replication; negative regulation of sister chromatid cohesion; and protein localization to chromatin. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WAPL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WAPL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WAPL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:86,257,496–86,258,064 | 264.0 kb | Distal (>10kb) Multiome | 89 | |
| chr10:86,346,106–86,346,932 | 175.2 kb | Distal (>10kb) Multiome | 239 | |
| chr10:86,362,777–86,364,049 | 158.5 kb | Distal (>10kb) Multiome | 244 | |
| chr10:86,365,694–86,367,849 | 155.0 kb | Distal (>10kb) Multiome | 419 | |
| chr10:86,376,705–86,377,696 | 144.4 kb | Distal (>10kb) Multiome | 545 | |
| chr10:86,389,055–86,390,403 | 132.1 kb | Distal (>10kb) Multiome | 377 | |
| chr10:86,399,617–86,401,886 | 121.6 kb | Distal (>10kb) Multiome | 946 | |
| chr10:86,520,920–86,522,476 | 79 bp | At TSS Multiome | 901 | |
| chr10:86,535,238–86,536,949 | 13.8 kb | Distal (>10kb) Multiome | 617 | |
| chr10:86,585,119–86,585,766 | 63.8 kb | Distal (>10kb) Multiome | 421 | |
| chr10:86,599,659–86,600,297 | 78.2 kb | Distal (>10kb) Multiome | 111 | |
| chr10:86,631,854–86,632,698 | 110.5 kb | Distal (>10kb) Multiome | 226 | |
| chr10:86,693,793–86,694,266 | 172.1 kb | Distal (>10kb) Multiome | 132 | |
| chr10:86,710,752–86,712,521 | 189.5 kb | Distal (>10kb) Multiome | 898 | |
| chr10:86,755,517–86,757,638 | 234.7 kb | Distal (>10kb) Multiome | 902 |
Genomic view of the WAPL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.