The protein encoded by this gene represents the catalytic subunit of DNA polymerase zeta, which functions in translesion DNA synthesis. The encoded protein can be found in mitochondria, where it protects DNA from damage. Defects in this gene are a cause of Mobius syndrome. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for REV3L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = REV3L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of REV3L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:111,251,962–111,252,726 | 231.5 kb | Distal (>10kb) Multiome | 110 | |
| chr6:111,258,884–111,259,808 | 224.4 kb | Distal (>10kb) Multiome | 945 | |
| chr6:111,477,255–111,477,926 | 6.1 kb | Proximal (<10kb) Multiome | 224 | |
| chr6:111,478,778–111,479,202 | 4.0 kb | Proximal (<10kb) | 295 | |
| chr6:111,482,095–111,484,488 | 76 bp | At TSS Multiome | 1155 | |
| chr6:111,551,467–111,552,823 | 68.2 kb | Distal (>10kb) Multiome HiCAR | 624 | |
| chr6:111,605,423–111,606,562 | 122.1 kb | Distal (>10kb) Multiome | 672 | |
| chr6:111,661,571–111,662,099 | 178.1 kb | Distal (>10kb) Multiome | 114 | |
| chr6:111,663,255–111,663,981 | 180.0 kb | Distal (>10kb) Multiome | 220 | |
| chr6:112,043,090–112,044,140 | 560.0 kb | Distal (>10kb) Multiome HiCAR | 680 |
Genomic view of the REV3L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.