This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ELOA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELOA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELOA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:23,483,306–23,485,071 | 259.0 kb | Distal (>10kb) Multiome | 659 | |
| chr1:23,530,568–23,531,711 | 212.1 kb | Distal (>10kb) Multiome | 775 | |
| chr1:23,539,704–23,540,280 | 203.5 kb | Distal (>10kb) Multiome | 668 | |
| chr1:23,554,367–23,556,627 | 188.5 kb | Distal (>10kb) Multiome | 961 | |
| chr1:23,558,135–23,559,925 | 183.9 kb | Distal (>10kb) Multiome | 932 | |
| chr1:23,598,114–23,599,073 | 144.8 kb | Distal (>10kb) Multiome | 329 | |
| chr1:23,691,587–23,692,258 | 51.7 kb | Distal (>10kb) Multiome | 876 | |
| chr1:23,742,958–23,744,137 | 97 bp | At TSS Multiome | 802 | |
| chr1:23,777,908–23,778,814 | 34.9 kb | Distal (>10kb) Multiome | 849 | |
| chr1:23,790,777–23,791,448 | 47.7 kb | Distal (>10kb) Multiome | 637 | |
| chr1:23,799,493–23,801,538 | 57.4 kb | Distal (>10kb) Multiome | 922 | |
| chr1:23,825,075–23,825,633 | 82.0 kb | Distal (>10kb) Multiome | 867 | |
| chr1:23,867,741–23,868,918 | 124.9 kb | Distal (>10kb) Multiome | 766 | |
| chr1:23,958,982–23,960,271 | 216.3 kb | Distal (>10kb) Multiome | 1051 | |
| chr1:23,979,815–23,981,031 | 236.9 kb | Distal (>10kb) Multiome | 1078 | |
| chr1:23,998,624–23,999,076 | 255.4 kb | Distal (>10kb) Multiome | 19 |
Genomic view of the ELOA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.