The protein encoded by this gene belongs to the ubiquitin-conjugating enzyme family. This protein interacts with RING finger proteins, and it can ubiquitinate huntingtin, the gene product for Huntington's disease. Known functions for this protein include a role in aggregate formation of expanded polyglutamine proteins and the suppression of apoptosis in polyglutamine diseases, a role in the dislocation of newly synthesized MHC class I heavy chains from the endoplasmic reticulum, and involvement in foam cell formation. Multiple transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for UBE2K. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UBE2K upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UBE2K, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:39,446,525–39,447,613 | 251.0 kb | Distal (>10kb) Multiome | 443 | |
| chr4:39,458,264–39,459,604 | 239.2 kb | Distal (>10kb) Multiome | 1000 | |
| chr4:39,526,691–39,528,369 | 170.5 kb | Distal (>10kb) Multiome | 1061 | |
| chr4:39,558,019–39,558,995 | 139.7 kb | Distal (>10kb) Multiome | 500 | |
| chr4:39,635,065–39,635,553 | 62.8 kb | Distal (>10kb) Multiome | 157 | |
| chr4:39,637,938–39,639,954 | 59.1 kb | Distal (>10kb) Multiome | 976 | |
| chr4:39,697,357–39,698,855 | 67 bp | At TSS Multiome | 866 | |
| chr4:39,706,789–39,707,295 | 8.7 kb | Proximal (<10kb) | 89 | |
| chr4:39,976,280–39,978,382 | 278.4 kb | Distal (>10kb) Multiome | 997 |
Genomic view of the UBE2K locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.