This gene encodes a protein that is part of the EGFR pathway. The protein is present at clatherin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for EPS15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EPS15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EPS15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:51,234,986–51,237,165 | 283.0 kb | Distal (>10kb) Multiome | 868 | |
| chr1:51,296,022–51,297,319 | 222.3 kb | Distal (>10kb) Multiome | 580 | |
| chr1:51,330,127–51,331,039 | 188.8 kb | Distal (>10kb) Multiome | 288 | |
| chr1:51,344,517–51,345,671 | 174.3 kb | Distal (>10kb) Multiome | 345 | |
| chr1:51,517,972–51,519,630 | 1.2 kb | Proximal (<10kb) Multiome | 979 | |
| chr1:51,616,886–51,617,753 | 97.8 kb | Distal (>10kb) Multiome | 626 | |
| chr1:51,729,098–51,730,258 | 210.4 kb | Distal (>10kb) Multiome | 828 |
Genomic view of the EPS15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.