ZC3H7B

zinc finger CCCH-type containing 7B | DKFZp434K0920, FLJ13787, KIAA1031, RoXaN

This gene encodes a protein that contains a tetratricopeptide repeat domain. The encoded protein also interacts with the rotavirus non-structural protein NSP3. [provided by RefSeq, Jul 2008]

Member of: DE-2 DE-2.45 Developmental clusters: GC1

Biological processes 12 terms

RNA binding (GO:0003723)metal ion binding (GO:0046872)miRNA binding (GO:0035198)miRNA binding (GO:0035198)miRNA binding (GO:0035198)miRNA processing (GO:0035196)miRNA processing (GO:0035196)miRNA processing (GO:0035196)nucleus (GO:0005634)post-transcriptional regulation of gene expression (GO:0010608)post-transcriptional regulation of gene expression (GO:0010608)protein binding (GO:0005515)

Expression (TPM)

TFs regulating ZC3H7B 0 TFs

Transcription factors with Perturb-seq knockdown data for ZC3H7B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZC3H7B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZC3H7B

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZC3H7B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr22:41,021,558–41,023,199	279.5 kb	Distal (>10kb) Multiome	978
chr22:41,091,127–41,092,906	209.9 kb	Distal (>10kb) Multiome	880
chr22:41,197,028–41,198,019	104.0 kb	Distal (>10kb) Multiome	640
chr22:41,204,902–41,205,619	96.3 kb	Distal (>10kb) Multiome	640
chr22:41,237,372–41,238,796	63.7 kb	Distal (>10kb) Multiome	302
chr22:41,285,539–41,286,833	15.2 kb	Distal (>10kb) Multiome	879
chr22:41,301,155–41,301,870	33 bp	At TSS Multiome	658
chr22:41,302,299–41,302,512	775 bp	At TSS	334
chr22:41,380,458–41,382,737	80.2 kb	Distal (>10kb) Multiome	925
chr22:41,413,486–41,414,305	112.3 kb	Distal (>10kb) Multiome	832
chr22:41,444,084–41,445,743	143.0 kb	Distal (>10kb) Multiome	607
chr22:41,446,165–41,449,007	145.4 kb	Distal (>10kb) Multiome	1188
chr22:41,468,341–41,469,602	167.4 kb	Distal (>10kb) Multiome	920
chr22:41,512,659–41,513,151	211.5 kb	Distal (>10kb) Multiome	354
chr22:41,543,855–41,544,782	243.0 kb	Distal (>10kb) Multiome	755
chr22:41,589,188–41,590,530	288.5 kb	Distal (>10kb) Multiome	758

Genome Browser

Genomic view of the ZC3H7B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.