Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ACACA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACACA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACACA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:36,600,997–36,602,715 | 805.3 kb | Distal (>10kb) Multiome HiCAR | 823 | |
| chr17:36,612,842–36,614,639 | 793.4 kb | Distal (>10kb) Multiome HiCAR | 111 | |
| chr17:37,124,503–37,125,029 | 282.1 kb | Distal (>10kb) Multiome | 41 | |
| chr17:37,358,363–37,360,066 | 47.5 kb | Distal (>10kb) Multiome | 859 | |
| chr17:37,406,418–37,407,500 | 171 bp | At TSS Multiome | 822 | |
| chr17:37,488,914–37,490,446 | 83.0 kb | Distal (>10kb) Multiome | 759 | |
| chr17:37,608,867–37,609,901 | 202.6 kb | Distal (>10kb) Multiome | 930 | |
| chr17:37,643,162–37,643,681 | 236.6 kb | Distal (>10kb) Multiome | 540 |
Genomic view of the ACACA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.