Enables GTPase binding activity; phosphatidylinositol 3-kinase inhibitor activity; and protein-membrane adaptor activity. Involved in several processes, including early endosome to late endosome transport; macroautophagy; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within endosome to lysosome transport. Located in autophagosome and phagophore assembly site membrane. Is extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. Part of phosphatidylinositol 3-kinase complex, class III. Is active in phagophore assembly site. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ATG14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ATG14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ATG14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:55,128,954–55,130,369 | 282.5 kb | Distal (>10kb) Multiome | 569 | |
| chr14:55,191,089–55,192,110 | 220.2 kb | Distal (>10kb) Multiome | 702 | |
| chr14:55,270,885–55,272,249 | 140.5 kb | Distal (>10kb) Multiome | 901 | |
| chr14:55,275,685–55,276,150 | 136.0 kb | Distal (>10kb) Multiome | 15 | |
| chr14:55,411,377–55,412,204 | 26 bp | At TSS Multiome | 795 | |
| chr14:55,579,635–55,581,317 | 168.3 kb | Distal (>10kb) Multiome | 720 | |
| chr14:56,579,396–56,580,264 | 1167.8 kb | Distal (>10kb) Multiome HiCAR | 723 | |
| chr14:57,364,988–57,365,748 | 1953.4 kb | Distal (>10kb) Multiome HiCAR | 54 |
Genomic view of the ATG14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.