Enables organic anion transmembrane transporter activity and prostaglandin transmembrane transporter activity. Involved in positive regulation of MAPK cascade; positive regulation of canonical NF-kappaB signal transduction; and prostaglandin transport. Located in basal plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SLCO3A1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLCO3A1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLCO3A1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:91,627,314–91,627,950 | 226.0 kb | Distal (>10kb) Multiome HiCAR | 113 | |
| chr15:91,630,194–91,631,378 | 222.9 kb | Distal (>10kb) Multiome HiCAR | 145 | |
| chr15:91,705,493–91,706,276 | 147.9 kb | Distal (>10kb) Multiome HiCAR | 47 | |
| chr15:91,706,338–91,706,969 | 147.1 kb | Distal (>10kb) Multiome HiCAR | 269 | |
| chr15:91,852,530–91,854,741 | 271 bp | At TSS Multiome | 593 | |
| chr15:91,856,031–91,856,429 | 2.3 kb | Proximal (<10kb) | 173 | |
| chr15:92,123,884–92,124,686 | 270.5 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the SLCO3A1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.