This 18-gene module includes ABCC1, TRAF3, NCOR2, NR2C2, and DIDO1, with enrichment in transcriptional regulation and nuclear cofactor functions. Knockdown of FOXH1, SMAD4, GATA4, SOX17, and SETDB1 activates this module. Knockdown of SOX11, SOX4, ZNF644, ZNF787, and DR1 represses this module.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.