The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha V subunit. This subunit associates with beta 1, beta 3, beta 5, beta 6 and beta 8 subunits. The heterodimer consisting of alpha V and beta 3 subunits is also known as the vitronectin receptor. This integrin may regulate angiogenesis and cancer progression. Alternative splicing results in multiple transcript variants. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Transcription factors with Perturb-seq knockdown data for ITGAV. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ITGAV upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ITGAV, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:186,485,510–186,487,147 | 103.8 kb | Distal (>10kb) Multiome | 1078 | |
| chr2:186,589,400–186,591,227 | 33 bp | At TSS Multiome | 1083 | |
| chr2:186,591,337–186,591,674 | 1.3 kb | Proximal (<10kb) | 156 | |
| chr2:186,591,929–186,592,427 | 1.9 kb | Proximal (<10kb) | 77 | |
| chr2:186,595,340–186,595,503 | 5.3 kb | Proximal (<10kb) | 224 | |
| chr2:186,595,755–186,595,926 | 5.7 kb | Proximal (<10kb) | 12 | |
| chr2:186,599,286–186,599,704 | 9.3 kb | Proximal (<10kb) | 26 | |
| chr2:186,693,562–186,694,912 | 104.1 kb | Distal (>10kb) Multiome | 615 | |
| chr2:186,734,517–186,735,706 | 145.4 kb | Distal (>10kb) Multiome | 224 | |
| chr2:186,848,474–186,849,953 | 259.1 kb | Distal (>10kb) Multiome | 410 |
Genomic view of the ITGAV locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.