This gene encodes a potential transmembrane protein and lies in a region where mutations and deletions have been associated with intellectual disability and autism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Transcription factors with Perturb-seq knockdown data for FAM120C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM120C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM120C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:54,043,795–54,045,108 | 138.7 kb | Distal (>10kb) Multiome | 824 | |
| chrX:54,182,249–54,183,769 | 152 bp | At TSS Multiome | 570 | |
| chrX:54,357,469–54,359,170 | 174.8 kb | Distal (>10kb) Multiome | 438 | |
| chrX:54,388,044–54,388,641 | 205.1 kb | Distal (>10kb) Multiome | 49 | |
| chrX:54,439,963–54,440,865 | 257.1 kb | Distal (>10kb) Multiome | 587 |
Genomic view of the FAM120C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.