This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SLC12A6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SLC12A6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SLC12A6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:34,038,314–34,039,346 | 299.3 kb | Distal (>10kb) Multiome | 694 | |
| chr15:34,101,337–34,102,390 | 236.1 kb | Distal (>10kb) Multiome | 810 | |
| chr15:34,209,514–34,210,513 | 128.1 kb | Distal (>10kb) Multiome | 775 | |
| chr15:34,224,706–34,225,419 | 113.0 kb | Distal (>10kb) Multiome | 856 | |
| chr15:34,318,518–34,319,085 | at TSS | At TSS | 385 | |
| chr15:34,337,012–34,338,557 | 88 bp | At TSS Multiome | 710 | |
| chr15:34,342,481–34,343,584 | 5.1 kb | Proximal (<10kb) Multiome | 845 | |
| chr15:34,366,166–34,368,049 | 28.3 kb | Distal (>10kb) Multiome | 922 | |
| chr15:34,436,551–34,437,460 | 98.9 kb | Distal (>10kb) Multiome | 165 | |
| chr15:34,494,295–34,495,393 | 156.7 kb | Distal (>10kb) Multiome | 115 | |
| chr15:34,514,176–34,515,283 | 176.9 kb | Distal (>10kb) Multiome | 588 | |
| chr15:34,582,613–34,584,384 | 245.7 kb | Distal (>10kb) Multiome | 711 |
Genomic view of the SLC12A6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.