Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. Several transcript variants, some protein-coding and others not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for USP10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = USP10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of USP10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:84,504,051–84,505,316 | 195.2 kb | Distal (>10kb) Multiome | 803 | |
| chr16:84,617,446–84,619,117 | 81.8 kb | Distal (>10kb) Multiome | 844 | |
| chr16:84,648,019–84,649,061 | 51.5 kb | Distal (>10kb) Multiome | 797 | |
| chr16:84,699,238–84,700,817 | 69 bp | At TSS Multiome | 876 | |
| chr16:84,819,303–84,820,380 | 119.9 kb | Distal (>10kb) Multiome | 496 | |
| chr16:84,841,652–84,842,331 | 142.0 kb | Distal (>10kb) Multiome | 196 | |
| chr16:84,876,654–84,877,363 | 177.0 kb | Distal (>10kb) Multiome | 54 |
Genomic view of the USP10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.