Enables acetyltransferase activator activity; enzyme binding activity; and zinc ion binding activity. Contributes to protein farnesyltransferase activity. Involved in protein farnesylation and regulation of microtubule-based movement. Part of microtubule associated complex and protein farnesyltransferase complex. Implicated in anxiety disorder. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for FNTB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FNTB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FNTB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:64,688,830–64,689,973 | 297.7 kb | Distal (>10kb) Multiome | 173 | |
| chr14:64,702,676–64,705,752 | 282.5 kb | Distal (>10kb) Multiome | 771 | |
| chr14:64,708,103–64,708,910 | 278.5 kb | Distal (>10kb) Multiome | 355 | |
| chr14:64,764,629–64,765,271 | 222.0 kb | Distal (>10kb) Multiome | 313 | |
| chr14:64,823,107–64,823,713 | 163.5 kb | Distal (>10kb) Multiome | 316 | |
| chr14:64,879,129–64,880,883 | 106.5 kb | Distal (>10kb) Multiome | 485 | |
| chr14:64,914,197–64,914,885 | 72.5 kb | Distal (>10kb) Multiome | 741 | |
| chr14:64,971,572–64,972,862 | 14.6 kb | Distal (>10kb) Multiome | 360 | |
| chr14:64,983,581–64,983,959 | 2.9 kb | Proximal (<10kb) | 91 | |
| chr14:64,986,666–64,987,558 | 165 bp | At TSS Multiome | 890 | |
| chr14:65,079,469–65,080,344 | 93.1 kb | Distal (>10kb) Multiome | 80 | |
| chr14:65,101,709–65,103,353 | 115.8 kb | Distal (>10kb) Multiome | 804 | |
| chr14:65,187,313–65,188,086 | 200.7 kb | Distal (>10kb) Multiome | 124 | |
| chr14:65,212,664–65,213,594 | 226.3 kb | Distal (>10kb) Multiome | 50 | |
| chr14:65,226,838–65,227,673 | 240.4 kb | Distal (>10kb) Multiome | 588 | |
| chr14:65,255,144–65,256,610 | 268.9 kb | Distal (>10kb) Multiome | 499 | |
| chr14:65,281,802–65,282,455 | 295.3 kb | Distal (>10kb) Multiome | 179 |
Genomic view of the FNTB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.