This module contains 18 genes including IRS1, SLC16A4, SENP1, TDP1, and KIF7, with top enriched terms related to metabolic processes, stress response, and cellular signaling. Knockdown of FOXA2 activates this module, while knockdown of SOX17 and GATA4 repress it. These regulatory patterns suggest this module functions in metabolic adaptation during endoderm differentiation.
Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).
| TF | Dir | NES | #gRNA | padj | Bind | OR |
|---|
GO terms and pathway annotations enriched in this gene set (g:Profiler).
| Term | Source | p-value | Genes |
|---|
No significant enrichment terms.
All genes assigned to this co-expression submodule.
| Gene | Type | Publications |
|---|
Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.