DE-2

DE-2.2

Submodule 72 genes

Non-coding RNA and metabolic regulation

This module contains 72 genes including TUG1, CSNK1A1, MAT2A, SNHG3, and KMT2E, with enrichment in non-coding RNA processing and one-carbon metabolism. Knockdown of ZIC3 activates this module. Knockdown of ZC3H3 represses this module.

Notable genes: TUG1 CSNK1A1 MAT2A SNHG3 KMT2E KTN1 PNN MTERF1 Top TFs: ZC3H3 ZIC3

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding
Perturbation only
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).


Module Genes (70)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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Low
High z