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DE-2.12

Submodule 18 genes

Proteasomal protein degradation and ubiquitin signaling

Module DE-2.12 contains 18 genes including SMARCA4, SMAD7, AXIN1, and INO80, with enrichment in proteasome-mediated ubiquitin-dependent protein catabolic process and proteasomal protein catabolic process. No transcription factor knockdown data are available for this module. No information on repressing transcription factors is provided.

Key terms: proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of ubiquitin-dependent protein catabolic process positive regulation of proteasomal ubiquitin-dependent protein catabolic process positive regulation of proteasomal protein catabolic process Notable genes: SMARCA4 SMAD7 AXIN1 INO80 MARK2 MLXIP VAC14 ANAPC7

TF Regulatory Network

Direction indicates the effect of TF knockdown on this submodule (↑ = KD upregulates; ↓ = KD downregulates).

Evidence: Direction: Max binding-only shown:
Perturbation + Binding ↑ ↓
Perturbation only ↑ ↓
Binding only
TF Dir NES #gRNA padj Bind OR

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).

Module Genes (18)

All genes assigned to this co-expression submodule.

Gene Type Publications

Local co-expression graph for member genes built from Hotspot z-scores. Adjust the z-score threshold and repulsion sliders to explore the neighbourhood.

Gene Co-expression Network

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