The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for MAP3K7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP3K7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP3K7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:90,294,706–90,297,702 | 290.1 kb | Distal (>10kb) Multiome | 679 | |
| chr6:90,385,858–90,387,296 | 200.9 kb | Distal (>10kb) Multiome | 295 | |
| chr6:90,479,062–90,479,622 | 107.6 kb | Distal (>10kb) Multiome | 421 | |
| chr6:90,494,141–90,494,851 | 92.6 kb | Distal (>10kb) Multiome | 92 | |
| chr6:90,586,586–90,587,698 | 92 bp | At TSS Multiome | 888 | |
| chr6:90,610,257–90,612,305 | 24.2 kb | Distal (>10kb) Multiome | 484 | |
| chr6:90,676,382–90,676,977 | 89.6 kb | Distal (>10kb) Multiome | 171 | |
| chr6:90,677,937–90,679,430 | 91.4 kb | Distal (>10kb) Multiome | 152 |
Genomic view of the MAP3K7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.