The protein encoded by this gene is a transcription factor that contains C2H2-type zinc-fingers. It also contains a positive regulatory domain, which has been found in several other zinc-finger transcription factors including those involved in B cell differentiation and tumor suppression. Studies of the mouse counterpart suggest that this protein may be involved in the development of the central nerve system (CNS), as well as in the pathogenesis of neuronal storage disease. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PRDM10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDM10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDM10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:129,750,339–129,751,168 | 252.0 kb | Distal (>10kb) Multiome | 421 | |
| chr11:129,815,544–129,816,526 | 186.9 kb | Distal (>10kb) Multiome | 315 | |
| chr11:129,894,845–129,896,318 | 107.2 kb | Distal (>10kb) Multiome | 678 | |
| chr11:130,001,573–130,003,849 | 61 bp | At TSS Multiome | 1080 | |
| chr11:130,068,597–130,071,216 | 66.9 kb | Distal (>10kb) Multiome | 898 | |
| chr11:130,076,579–130,077,560 | 74.2 kb | Distal (>10kb) Multiome | 129 | |
| chr11:130,146,013–130,146,727 | 143.6 kb | Distal (>10kb) Multiome | 413 | |
| chr11:130,159,259–130,160,341 | 157.0 kb | Distal (>10kb) Multiome | 309 | |
| chr11:130,212,937–130,213,600 | 210.4 kb | Distal (>10kb) Multiome | 321 |
Genomic view of the PRDM10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.