SMAD7

SMAD7

SMAD family member 7 | MADH7, MADH8

The protein encoded by this gene is a nuclear protein that binds the E3 ubiquitin ligase SMURF2. Upon binding, this complex translocates to the cytoplasm, where it interacts with TGF-beta receptor type-1 (TGFBR1), leading to the degradation of both the encoded protein and TGFBR1. Expression of this gene is induced by TGFBR1. Variations in this gene are a cause of susceptibility to colorectal cancer type 3 (CRCS3). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Member of: DE-2 DE-2.12 Developmental clusters: GC2

Biological processes 89 terms

I-SMAD binding (GO:0070411)I-SMAD binding (GO:0070411)I-SMAD binding (GO:0070411)SMAD protein signal transduction (GO:0060395)SMAD protein signal transduction (GO:0060395)SMAD protein signal transduction (GO:0060395)activin receptor binding (GO:0070697)activin receptor binding (GO:0070697)adherens junction (GO:0005912)adherens junction assembly (GO:0034333)anatomical structure morphogenesis (GO:0009653)artery morphogenesis (GO:0048844)artery morphogenesis (GO:0048844)beta-catenin binding (GO:0008013)beta-catenin destruction complex disassembly (GO:1904886)cell differentiation (GO:0030154)cellular response to growth factor stimulus (GO:0071363)chromatin (GO:0000785)ciliary basal body (GO:0036064)collagen binding (GO:0005518)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)fibrillar center (GO:0001650)heteromeric SMAD protein complex (GO:0071144)negative regulation of BMP signaling pathway (GO:0030514)negative regulation of BMP signaling pathway (GO:0030514)negative regulation of SMAD protein signal transduction (GO:0060392)negative regulation of SMAD protein signal transduction (GO:0060392)negative regulation of SMAD protein signal transduction (GO:0060392)negative regulation of SMAD protein signal transduction (GO:0060392)negative regulation of T cell cytokine production (GO:0002725)negative regulation of T cell cytokine production (GO:0002725)negative regulation of T-helper 17 cell differentiation (GO:2000320)negative regulation of T-helper 17 cell differentiation (GO:2000320)negative regulation of T-helper 17 type immune response (GO:2000317)negative regulation of T-helper 17 type immune response (GO:2000317)negative regulation of activin receptor signaling pathway (GO:0032926)negative regulation of activin receptor signaling pathway (GO:0032926)negative regulation of cell differentiation (GO:0045596)negative regulation of cell migration (GO:0030336)negative regulation of chondrocyte proliferation (GO:1902731)negative regulation of epithelial to mesenchymal transition (GO:0010719)negative regulation of ossification (GO:0030279)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)negative regulation of transforming growth factor beta receptor signaling pathway (GO:0030512)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)plasma membrane (GO:0005886)positive regulation of cell-cell adhesion mediated by cadherin (GO:2000049)positive regulation of cell-cell adhesion mediated by cadherin (GO:2000049)positive regulation of chondrocyte hypertrophy (GO:1903043)positive regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032436)protein binding (GO:0005515)protein stabilization (GO:0050821)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)protein-containing complex disassembly (GO:0032984)protein-containing complex localization (GO:0031503)regulation of DNA-templated transcription (GO:0006355)regulation of cardiac muscle contraction (GO:0055117)regulation of cardiac muscle contraction (GO:0055117)regulation of epithelial to mesenchymal transition (GO:0010717)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transforming growth factor beta receptor signaling pathway (GO:0017015)regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373)regulation of ventricular cardiac muscle cell membrane depolarization (GO:0060373)response to laminar fluid shear stress (GO:0034616)transcription corepressor activity (GO:0003714)transcription regulator complex (GO:0005667)transcription regulator inhibitor activity (GO:0140416)transcription regulator inhibitor activity (GO:0140416)transcription regulator inhibitor activity (GO:0140416)transforming growth factor beta receptor signaling pathway (GO:0007179)transforming growth factor beta receptor superfamily signaling pathway (GO:0141091)type I transforming growth factor beta receptor binding (GO:0034713)type I transforming growth factor beta receptor binding (GO:0034713)ubiquitin protein ligase binding (GO:0031625)ubiquitin-like ligase-substrate adaptor activity (GO:1990756)ureteric bud development (GO:0001657)ventricular cardiac muscle tissue morphogenesis (GO:0055010)ventricular cardiac muscle tissue morphogenesis (GO:0055010)ventricular septum morphogenesis (GO:0060412)ventricular septum morphogenesis (GO:0060412)

Expression (TPM)

TFs regulating SMAD7 0 TFs

Transcription factors with Perturb-seq knockdown data for SMAD7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMAD7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to SMAD7

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMAD7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr18:48,776,915–48,777,546	171.3 kb	Distal (>10kb) Multiome HiCAR	356
	chr18:48,802,644–48,803,302	145.5 kb	Distal (>10kb) Multiome	62
	chr18:48,948,073–48,948,351	153 bp	At TSS	125
	chr18:48,948,448–48,949,392	146 bp	At TSS Multiome	699
	chr18:48,949,854–48,950,864	1.3 kb	Proximal (<10kb)	465
	chr18:48,951,393–48,953,299	3.7 kb	Proximal (<10kb) Multiome	824
	chr18:48,959,553–48,960,608	11.5 kb	Distal (>10kb) Multiome	373
	chr18:48,975,259–48,976,821	27.6 kb	Distal (>10kb) Multiome	578
	chr18:49,021,444–49,022,101	73.3 kb	Distal (>10kb) Multiome	464
	chr18:49,252,346–49,252,812	304.0 kb	Distal (>10kb) Multiome HiCAR	15
	chr18:49,460,079–49,460,928	512.2 kb	Distal (>10kb) Multiome HiCAR	871

Genome Browser

Genomic view of the SMAD7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.