This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Transcription factors with Perturb-seq knockdown data for MDM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MDM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MDM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:68,538,810–68,539,554 | 269.0 kb | Distal (>10kb) Multiome | 347 | |
| chr12:68,610,127–68,611,767 | 197.4 kb | Distal (>10kb) Multiome | 846 | |
| chr12:68,686,562–68,687,457 | 121.3 kb | Distal (>10kb) Multiome | 987 | |
| chr12:68,745,790–68,746,910 | 62.0 kb | Distal (>10kb) Multiome | 899 | |
| chr12:68,804,279–68,805,301 | 3.3 kb | Proximal (<10kb) Multiome | 497 | |
| chr12:68,807,325–68,809,299 | 711 bp | At TSS Multiome | 1178 | |
| chr12:68,813,032–68,813,198 | 4.9 kb | Proximal (<10kb) | 55 | |
| chr12:68,932,729–68,933,748 | 125.1 kb | Distal (>10kb) Multiome | 457 |
Genomic view of the MDM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.