The protein encoded by this gene is expressed in the brain, predominantly in the parietal and frontal cortex as well as in dorsal root ganglia. It is localized to the peroxisome, and is implicated in resistance to oxidative stress. It likely functions by increasing superoxide dismutase (SOD) activity, but itself has no direct SOD activity. Studies in mice show that this gene confers low seizure threshold, and may also enhance epileptogenesis. [provided by RefSeq, Jun 2011]
Transcription factors with Perturb-seq knockdown data for SZT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SZT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SZT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:43,147,490–43,148,180 | 242.1 kb | Distal (>10kb) Multiome | 318 | |
| chr1:43,172,043–43,172,806 | 217.4 kb | Distal (>10kb) Multiome | 767 | |
| chr1:43,270,344–43,271,458 | 119.1 kb | Distal (>10kb) Multiome HiCAR | 301 | |
| chr1:43,285,284–43,285,996 | 104.3 kb | Distal (>10kb) Multiome | 403 | |
| chr1:43,348,408–43,350,097 | 40.6 kb | Distal (>10kb) Multiome | 819 | |
| chr1:43,358,112–43,359,560 | 31.1 kb | Distal (>10kb) Multiome | 818 | |
| chr1:43,366,277–43,366,800 | 23.4 kb | Distal (>10kb) Multiome | 226 | |
| chr1:43,366,988–43,368,619 | 21.7 kb | Distal (>10kb) Multiome | 991 | |
| chr1:43,389,284–43,390,213 | 77 bp | At TSS Multiome | 905 | |
| chr1:43,452,851–43,454,257 | 63.5 kb | Distal (>10kb) Multiome | 455 | |
| chr1:43,454,433–43,454,997 | 64.8 kb | Distal (>10kb) Multiome | 267 | |
| chr1:43,530,512–43,532,007 | 141.0 kb | Distal (>10kb) Multiome | 520 | |
| chr1:43,545,657–43,546,353 | 156.1 kb | Distal (>10kb) Multiome | 445 | |
| chr1:43,549,934–43,550,659 | 160.4 kb | Distal (>10kb) Multiome | 343 | |
| chr1:43,565,502–43,566,158 | 175.9 kb | Distal (>10kb) Multiome | 173 | |
| chr1:43,649,463–43,650,795 | 260.2 kb | Distal (>10kb) Multiome | 997 |
Genomic view of the SZT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.