The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. Overexpression of this gene has been shown to induce apoptosis in cells. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene. [provided by RefSeq, May 2009]
Transcription factors with Perturb-seq knockdown data for BCL2L14. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BCL2L14 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BCL2L14, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:11,812,583–11,813,622 | 236.7 kb | Distal (>10kb) Multiome | 258 | |
| chr12:11,855,587–11,856,644 | 193.7 kb | Distal (>10kb) Multiome | 245 | |
| chr12:12,009,039–12,009,753 | 40.5 kb | Distal (>10kb) Multiome | 327 | |
| chr12:12,061,146–12,061,376 | 9.6 kb | Proximal (<10kb) | 3 | |
| chr12:12,063,709–12,064,393 | 6.5 kb | Proximal (<10kb) | 15 | |
| chr12:12,064,661–12,065,057 | 5.9 kb | Proximal (<10kb) | 20 | |
| chr12:12,072,157–12,072,567 | 1.2 kb | Proximal (<10kb) | 132 | |
| chr12:12,266,376–12,267,615 | 217.3 kb | Distal (>10kb) Multiome | 1095 | |
| chr12:12,349,790–12,350,566 | 300.4 kb | Distal (>10kb) Multiome | 671 | |
| chr12:12,695,955–12,697,008 | 646.5 kb | Distal (>10kb) Multiome HiCAR | 568 |
Genomic view of the BCL2L14 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.