This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for LATS2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = LATS2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of LATS2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:20,773,202–20,774,439 | 287.7 kb | Distal (>10kb) Multiome | 873 | |
| chr13:20,902,026–20,903,305 | 158.7 kb | Distal (>10kb) Multiome | 749 | |
| chr13:21,060,253–21,061,988 | 2 bp | At TSS Multiome | 817 | |
| chr13:21,075,367–21,076,193 | 14.2 kb | Distal (>10kb) Multiome | 151 | |
| chr13:21,139,877–21,141,067 | 78.9 kb | Distal (>10kb) Multiome | 784 | |
| chr13:21,176,109–21,177,241 | 115.1 kb | Distal (>10kb) Multiome | 933 | |
| chr13:21,297,800–21,298,863 | 236.6 kb | Distal (>10kb) Multiome | 776 | |
| chr13:21,326,200–21,327,030 | 265.0 kb | Distal (>10kb) Multiome | 179 |
Genomic view of the LATS2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.