Enables cohesin loader activity. Involved in maintenance of mitotic sister chromatid cohesion. Located in chromatin and nuclear body. Part of Scc2-Scc4 cohesin loading complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MAU2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAU2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAU2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:19,032,820–19,034,059 | 287.1 kb | Distal (>10kb) Multiome | 944 | |
| chr19:19,063,253–19,064,386 | 257.1 kb | Distal (>10kb) Multiome | 781 | |
| chr19:19,105,310–19,106,514 | 215.1 kb | Distal (>10kb) Multiome | 447 | |
| chr19:19,110,429–19,110,857 | 210.1 kb | Distal (>10kb) Multiome | 131 | |
| chr19:19,119,998–19,121,362 | 200.3 kb | Distal (>10kb) Multiome | 304 | |
| chr19:19,138,171–19,138,698 | 182.4 kb | Distal (>10kb) Multiome | 642 | |
| chr19:19,170,055–19,170,692 | 150.5 kb | Distal (>10kb) Multiome | 403 | |
| chr19:19,191,912–19,193,209 | 128.3 kb | Distal (>10kb) Multiome | 939 | |
| chr19:19,202,895–19,203,773 | 117.4 kb | Distal (>10kb) Multiome | 599 | |
| chr19:19,224,938–19,225,553 | 95.6 kb | Distal (>10kb) Multiome | 646 | |
| chr19:19,261,403–19,261,973 | 59.1 kb | Distal (>10kb) Multiome | 205 | |
| chr19:19,272,869–19,273,464 | 47.7 kb | Distal (>10kb) Multiome | 236 | |
| chr19:19,320,030–19,321,531 | 153 bp | At TSS Multiome | 839 | |
| chr19:19,342,616–19,343,003 | at TSS | At TSS | 289 | |
| chr19:19,384,944–19,386,424 | 64.8 kb | Distal (>10kb) Multiome | 788 | |
| chr19:19,405,072–19,406,890 | 84.8 kb | Distal (>10kb) Multiome | 1014 | |
| chr19:19,461,886–19,462,726 | 141.5 kb | Distal (>10kb) Multiome | 345 | |
| chr19:19,515,735–19,516,510 | 195.4 kb | Distal (>10kb) Multiome | 824 | |
| chr19:19,532,119–19,532,674 | 211.6 kb | Distal (>10kb) Multiome | 405 | |
| chr19:19,538,087–19,538,726 | 217.5 kb | Distal (>10kb) Multiome | 255 | |
| chr19:19,539,681–19,541,846 | 220.5 kb | Distal (>10kb) Multiome | 352 | |
| chr19:19,575,151–19,576,000 | 254.8 kb | Distal (>10kb) Multiome | 128 | |
| chr19:19,618,285–19,619,315 | 298.0 kb | Distal (>10kb) Multiome | 414 |
Genomic view of the MAU2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.