PPP1R10

protein phosphatase 1 regulatory subunit 10 | CAT53, FB19, PNUTS, p99

This gene encodes a protein phosphatase 1 binding protein. The encoded protein plays a role in many cellular processes including cell cycle progression, DNA repair and apoptosis by regulating the activity of protein phosphatase 1. This gene lies within the major histocompatibility complex class I region on chromosome 6, and alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Jul 2012]

Member of: DE-2 DE-2.15 Developmental clusters: GC6 GC3

Biological processes 35 terms

PTW/PP1 phosphatase complex (GO:0072357)PTW/PP1 phosphatase complex (GO:0072357)PTW/PP1 phosphatase complex (GO:0072357)PTW/PP1 phosphatase complex (GO:0072357)RNA binding (GO:0003723)RNA polymerase II promoter clearance (GO:0001111)chromatin (GO:0000785)chromatin (GO:0000785)chromatin (GO:0000785)chromatin (GO:0000785)chromosome (GO:0005694)chromosome, telomeric region (GO:0000781)enzyme-substrate adaptor activity (GO:0140767)enzyme-substrate adaptor activity (GO:0140767)metal ion binding (GO:0046872)negative regulation of cardiac muscle cell apoptotic process (GO:0010667)negative regulation of mitotic DNA damage checkpoint (GO:1904290)negative regulation of transcription elongation by RNA polymerase II (GO:0034244)nuclear body (GO:0016604)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of telomere maintenance (GO:0032206)positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled (GO:2000806)positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled (GO:2000806)positive regulation of transcription elongation by RNA polymerase II (GO:0032968)protein binding (GO:0005515)protein import into nucleus (GO:0006606)protein phosphatase 1 binding (GO:0008157)protein phosphatase inhibitor activity (GO:0004864)protein phosphatase inhibitor activity (GO:0004864)protein phosphatase inhibitor activity (GO:0004864)protein phosphatase regulator activity (GO:0019888)protein stabilization (GO:0050821)

Expression (TPM)

TFs regulating PPP1R10 0 TFs

Transcription factors with Perturb-seq knockdown data for PPP1R10. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PPP1R10 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to PPP1R10

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PPP1R10, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr6:30,325,606–30,327,611	290.3 kb	Distal (>10kb) Multiome	1043
chr6:30,344,843–30,345,715	272.0 kb	Distal (>10kb) Multiome	892
chr6:30,357,696–30,358,238	259.4 kb	Distal (>10kb) Multiome	207
chr6:30,466,230–30,466,713	150.7 kb	Distal (>10kb) Multiome	369
chr6:30,489,117–30,490,512	126.9 kb	Distal (>10kb) Multiome	750
chr6:30,516,006–30,516,707	100.9 kb	Distal (>10kb) Multiome	739
chr6:30,555,407–30,557,765	60.6 kb	Distal (>10kb) Multiome	1161
chr6:30,570,822–30,571,949	45.8 kb	Distal (>10kb) Multiome	1000
chr6:30,614,393–30,615,939	2.0 kb	Proximal (<10kb) Multiome	837
chr6:30,616,770–30,618,155	287 bp	At TSS Multiome	1072
chr6:30,626,560–30,627,206	9.6 kb	Proximal (<10kb) Multiome	802
chr6:30,646,505–30,648,035	30.1 kb	Distal (>10kb) Multiome	961
chr6:30,672,571–30,673,266	55.7 kb	Distal (>10kb) Multiome	812
chr6:30,679,032–30,679,479	61.9 kb	Distal (>10kb) Multiome	603
chr6:30,686,268–30,688,032	70.0 kb	Distal (>10kb) Multiome	801
chr6:30,690,445–30,691,240	73.7 kb	Distal (>10kb) Multiome	644
chr6:30,716,986–30,717,874	100.2 kb	Distal (>10kb) Multiome	1059
chr6:30,719,428–30,720,577	102.9 kb	Distal (>10kb) Multiome	724
chr6:30,721,307–30,722,103	104.3 kb	Distal (>10kb) Multiome	872
chr6:30,725,731–30,726,564	109.0 kb	Distal (>10kb) Multiome	478
chr6:30,740,996–30,745,094	125.5 kb	Distal (>10kb) Multiome	1233
chr6:30,763,647–30,765,193	147.2 kb	Distal (>10kb) Multiome	850
chr6:30,880,638–30,881,295	263.7 kb	Distal (>10kb) Multiome	124
chr6:30,882,560–30,883,422	265.6 kb	Distal (>10kb) Multiome	308
chr6:30,883,625–30,885,122	267.1 kb	Distal (>10kb) Multiome	538
chr6:30,907,770–30,908,494	290.9 kb	Distal (>10kb) Multiome	1005
chr6:30,913,674–30,914,800	297.0 kb	Distal (>10kb) Multiome	944

Genome Browser

Genomic view of the PPP1R10 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.