Enables several functions, including clathrin heavy chain binding activity; hyaluronic acid binding activity; and hyalurononglucosaminidase activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of protein phosphorylation; and positive regulation of protein targeting to membrane. Located in several cellular components, including clathrin-coated endocytic vesicle; endoplasmic reticulum; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CEMIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEMIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEMIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:80,503,942–80,504,568 | 275.0 kb | Distal (>10kb) Multiome | 13 | |
| chr15:80,694,769–80,696,059 | 84.1 kb | Distal (>10kb) Multiome | 455 | |
| chr15:80,778,964–80,780,209 | 169 bp | At TSS Multiome | 528 | |
| chr15:80,780,345–80,780,949 | 1.4 kb | Proximal (<10kb) Multiome | 676 | |
| chr15:80,989,298–80,990,315 | 210.5 kb | Distal (>10kb) Multiome | 780 | |
| chr15:81,000,317–81,003,329 | 221.5 kb | Distal (>10kb) Multiome | 865 |
Genomic view of the CEMIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.