The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for RNF13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RNF13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RNF13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:149,618,663–149,619,621 | 194.2 kb | Distal (>10kb) Multiome | 241 | |
| chr3:149,656,829–149,659,185 | 155.1 kb | Distal (>10kb) Multiome | 974 | |
| chr3:149,716,922–149,717,701 | 95.8 kb | Distal (>10kb) Multiome | 161 | |
| chr3:149,752,004–149,753,499 | 60.5 kb | Distal (>10kb) Multiome | 991 | |
| chr3:149,808,100–149,808,476 | 4.3 kb | Proximal (<10kb) | 179 | |
| chr3:149,812,342–149,813,957 | 123 bp | At TSS Multiome | 918 | |
| chr3:149,969,831–149,971,970 | 158.0 kb | Distal (>10kb) Multiome | 920 | |
| chr3:150,097,150–150,098,142 | 284.4 kb | Distal (>10kb) Multiome | 220 |
Genomic view of the RNF13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.