This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for WDR26. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WDR26 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WDR26, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:224,182,841–224,184,249 | 251.6 kb | Distal (>10kb) Multiome | 901 | |
| chr1:224,329,851–224,330,705 | 104.5 kb | Distal (>10kb) Multiome | 865 | |
| chr1:224,356,549–224,357,612 | 77.9 kb | Distal (>10kb) Multiome | 791 | |
| chr1:224,434,594–224,435,312 | 78 bp | At TSS Multiome | 865 | |
| chr1:224,498,011–224,499,031 | 63.8 kb | Distal (>10kb) Multiome | 326 | |
| chr1:224,502,820–224,504,228 | 68.8 kb | Distal (>10kb) Multiome | 820 | |
| chr1:224,615,699–224,617,266 | 181.4 kb | Distal (>10kb) Multiome | 511 | |
| chr1:224,639,152–224,640,098 | 204.8 kb | Distal (>10kb) Multiome | 68 | |
| chr1:224,700,754–224,701,811 | 266.5 kb | Distal (>10kb) Multiome | 221 | |
| chr1:224,720,167–224,720,687 | 285.6 kb | Distal (>10kb) Multiome | 31 | |
| chr1:224,929,306–224,930,138 | 494.9 kb | Distal (>10kb) Multiome HiCAR | 992 |
Genomic view of the WDR26 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.