The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Transcription factors with Perturb-seq knockdown data for CLIP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CLIP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CLIP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:122,155,564–122,156,340 | 266.7 kb | Distal (>10kb) Multiome | 197 | |
| chr12:122,182,856–122,183,527 | 239.4 kb | Distal (>10kb) Multiome | 228 | |
| chr12:122,203,186–122,204,669 | 219.0 kb | Distal (>10kb) Multiome | 500 | |
| chr12:122,225,485–122,227,116 | 196.4 kb | Distal (>10kb) Multiome | 1019 | |
| chr12:122,265,933–122,267,109 | 156.1 kb | Distal (>10kb) Multiome | 1060 | |
| chr12:122,399,610–122,399,775 | 238 bp | At TSS | 402 | |
| chr12:122,399,986–122,400,160 | at TSS | At TSS | 502 | |
| chr12:122,421,844–122,422,754 | 221 bp | At TSS Multiome HiCAR | 685 | |
| chr12:122,500,206–122,501,493 | 78.4 kb | Distal (>10kb) Multiome | 955 | |
| chr12:122,526,435–122,527,753 | 104.4 kb | Distal (>10kb) Multiome | 956 |
Genomic view of the CLIP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.