The protein encoded by this gene is a cytoplasmic kinase that is structurally similar to the yeast Ste20p kinase, which acts upstream of the stress-induced mitogen-activated protein kinase cascade. The encoded protein can phosphorylate myelin basic protein and undergoes autophosphorylation. A caspase-cleaved fragment of the encoded protein has been shown to be capable of phosphorylating histone H2B. The particular phosphorylation catalyzed by this protein has been correlated with apoptosis, and it's possible that this protein induces the chromatin condensation observed in this process. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for STK4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = STK4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of STK4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:44,745,652–44,746,316 | 220.6 kb | Distal (>10kb) Multiome | 321 | |
| chr20:44,810,403–44,810,885 | 156.0 kb | Distal (>10kb) Multiome | 181 | |
| chr20:44,884,968–44,886,235 | 80.9 kb | Distal (>10kb) Multiome | 913 | |
| chr20:44,909,510–44,910,396 | 56.5 kb | Distal (>10kb) Multiome | 810 | |
| chr20:44,911,292–44,911,995 | 54.8 kb | Distal (>10kb) Multiome | 532 | |
| chr20:44,960,068–44,960,912 | 6.0 kb | Proximal (<10kb) Multiome | 1025 | |
| chr20:44,966,035–44,967,090 | 56 bp | At TSS Multiome | 1001 | |
| chr20:45,098,253–45,098,840 | 132.1 kb | Distal (>10kb) Multiome | 171 |
Genomic view of the STK4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.