Transcription factors with Perturb-seq knockdown data for FAM151B-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FAM151B-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FAM151B-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:80,204,750–80,205,627 | 283.0 kb | Distal (>10kb) Multiome | 594 | |
| chr5:80,255,259–80,256,736 | 232.0 kb | Distal (>10kb) Multiome | 873 | |
| chr5:80,257,220–80,257,979 | 230.4 kb | Distal (>10kb) Multiome | 496 | |
| chr5:80,407,421–80,408,673 | 80.0 kb | Distal (>10kb) Multiome | 954 | |
| chr5:80,481,383–80,481,569 | 6.5 kb | Proximal (<10kb) | 171 | |
| chr5:80,487,503–80,488,829 | 96 bp | At TSS Multiome | 871 | |
| chr5:80,493,589–80,493,935 | 5.5 kb | Proximal (<10kb) | 42 | |
| chr5:80,554,442–80,555,055 | 66.7 kb | Distal (>10kb) Multiome | 148 | |
| chr5:80,568,978–80,570,765 | 82.2 kb | Distal (>10kb) Multiome | 431 | |
| chr5:80,654,076–80,655,416 | 166.8 kb | Distal (>10kb) Multiome HiCAR | 820 |
Genomic view of the FAM151B-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.