This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
Transcription factors with Perturb-seq knockdown data for FBXW7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = FBXW7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of FBXW7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:152,515,941–152,516,444 | 19.9 kb | Distal (>10kb) Multiome | 126 | |
| chr4:152,534,805–152,535,174 | at TSS | At TSS | 235 | |
| chr4:152,535,271–152,537,069 | 128 bp | At TSS Multiome | 955 | |
| chr4:152,540,175–152,541,082 | 4.5 kb | Proximal (<10kb) Multiome | 203 | |
| chr4:152,619,935–152,621,307 | 84.4 kb | Distal (>10kb) Multiome | 92 | |
| chr4:152,679,625–152,680,356 | 143.9 kb | Distal (>10kb) Multiome | 414 | |
| chr4:152,735,720–152,736,367 | 199.9 kb | Distal (>10kb) Multiome | 141 | |
| chr4:152,779,006–152,780,778 | 243.8 kb | Distal (>10kb) Multiome | 903 | |
| chr4:152,808,636–152,809,308 | 272.8 kb | Distal (>10kb) Multiome | 113 |
Genomic view of the FBXW7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.