This gene encodes a ubiquitous transcriptional enhancer factor that is a member of the TEA/ATTS domain family. This protein directs the transactivation of a wide variety of genes and, in placental cells, also acts as a transcriptional repressor. Mutations in this gene cause Sveinsson's chorioretinal atrophy. Additional transcript variants have been described but their full-length natures have not been experimentally verified. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for TEAD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEAD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEAD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:12,376,994–12,378,481 | 296.5 kb | Distal (>10kb) Multiome | 582 | |
| chr11:12,673,794–12,675,368 | 83 bp | At TSS Multiome | 794 | |
| chr11:12,680,314–12,681,166 | 6.2 kb | Proximal (<10kb) Multiome | 359 | |
| chr11:12,687,771–12,688,305 | 13.6 kb | Distal (>10kb) Multiome | 192 | |
| chr11:12,724,623–12,725,092 | 50.4 kb | Distal (>10kb) Multiome | 375 | |
| chr11:12,746,606–12,747,125 | 72.4 kb | Distal (>10kb) Multiome | 393 | |
| chr11:12,794,496–12,795,683 | 120.6 kb | Distal (>10kb) Multiome | 173 | |
| chr11:12,800,108–12,800,919 | 126.1 kb | Distal (>10kb) Multiome | 317 | |
| chr11:12,828,007–12,828,591 | 154.0 kb | Distal (>10kb) Multiome | 395 | |
| chr11:12,864,406–12,865,214 | 190.4 kb | Distal (>10kb) Multiome | 304 | |
| chr11:12,914,362–12,914,893 | 240.3 kb | Distal (>10kb) Multiome | 260 |
Genomic view of the TEAD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.