DE-4

Supermodule 1046 genes

Actin cytoskeleton and circulatory system development

This 1090-gene module includes CXCR4, JAK2, and CCL2, with strong enrichment for actin cytoskeleton organization, actomyosin structures, and circulatory system development. Knockdown of CTBP1, SOX11, and SOX4 activates this module. Knockdown of TCEB3, DNAJC19, and ZNF431 represses this module.

Key terms: anatomical structure development anatomical structure morphogenesis cell adhesion multicellular organismal process developmental process Notable genes: CXCR4 JAK2 CCL2 NPPB IGF1R SP1 CDKN1B IDH1 Top TFs: CTBP1 SOX11 TCEB3 DNAJC19 SOX4

TF Regulatory Network

Direction indicates the effect of TF knockdown on this module (↑ = KD upregulates; ↓ = KD downregulates).

Perturbation + Binding ↑ ↓

Perturbation only ↑ ↓

Binding only

TF	Dir	NES	#gRNA	padj	Bind	OR

Submodules (32)

Finer-grained co-expression clusters within this supermodule, each with a distinct functional signature.

Submodule	Genes	Notable genes
DE-4.1	67	CXCR4 IDH1 HSPB1 CDC42 PKM
DE-4.2	57	FOXO3 LMNA WWTR1 MAP2K1 CTNND1
DE-4.3	48	IGF1R APC TCF7L2 CDH2 MYH9
DE-4.4	41	SP1 PLAUR ETS1 MSH6 NEDD4
DE-4.5	34	NPPB CCN2 NFKBIA WFDC2 EIF4EBP1
DE-4.6	28	PNPLA3 STAT4 EDNRA JUP ST3GAL5
DE-4.7	23	CFLAR FZD7 PLAGL1 C1GALT1 GRPR
DE-4.8	23	GAS5 CDKN1C MAP1LC3A BBC3 TSPO
DE-4.9	22	ERBB4 NTN1 NRP2 CNTNAP2 PARD3
DE-4.10	22	CHFR PLAG1 BCL11B CAST CPEB4
DE-4.11	21	RIGI RARB PLCE1 PRKCQ S1PR3
DE-4.12	19	JAK2 MGMT SPINK5 PDGFD CRPPA
DE-4.13	18	SMAD3 ANGPT2 SYNE1 PALLD SERINC5
DE-4.14	18	STAT5B AXIN2 MYO5B SGPL1 WNK3
DE-4.15	17	TJP1 ATP2A2 MERTK WNK1 SPTAN1
DE-4.16	16	IQGAP1 ARRB1 ALDH3A2 FLVCR1 BASP1
DE-4.17	16	CAPN1 SNHG16 GIPC1 PLIN3 FLII
DE-4.18	15	MSH2 ATXN1 SGMS1 DAB1 SPOCK1
DE-4.19	15	CCN1 PRKCI MAP3K8 ACTN1 NECTIN2
DE-4.20	15	RALBP1 HGS TNIP2 MKNK2 CHMP1A
DE-4.21	14	ACKR3 MECOM GATA6 SLC1A1 OTX2
DE-4.22	13	ABCA1 OGA AMBRA1 SPRED2 CHD2
DE-4.23	13	CCL2 FGF8 CCNG1 TRIP10 FZD8
DE-4.24	13	HSPG2 PKP2 LAMB1 CACNB2 MTHFD1L
DE-4.25	12	SRF PRKAG2 DAPK3 FHOD1 FBLIM1
DE-4.26	11	PIK3CB VCL EDA FLNB AKAP13
DE-4.27	11	FERMT2 FRZB DIO3 STK26 RRBP1
DE-4.28	11	PAX6 SLC34A2 MTUS1 SLC26A2 LRAT
DE-4.29	11	SATB1 KDM6B BTG2 TERF2IP TP53INP1
DE-4.30	10	HMGA2 ITGB5 MYOCD TNFRSF21 COLEC12
DE-4.31	10	KLF8 RBM20 MAK ZNF462 PPFIBP1
DE-4.32	10	PRKCZ TNK2 SH3KBP1 PPP3CC ERGIC1

Module Genes

All genes assigned to this co-expression supermodule.

Gene	Type	Submodule	Publications

Enriched Terms

GO terms and pathway annotations enriched in this gene set (g:Profiler).