MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. The protein encoded by this gene is one of the light chain subunits and can associate with either MAP1A or MAP1B. Two transcript variants encoding different isoforms have been found for this gene. The expression of variant 1 is suppressed in many tumor cell lines, suggesting that may be involved in carcinogenesis. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for MAP1LC3A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MAP1LC3A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MAP1LC3A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:34,302,649–34,303,619 | 255.5 kb | Distal (>10kb) Multiome | 1055 | |
| chr20:34,311,332–34,311,914 | 247.2 kb | Distal (>10kb) Multiome | 577 | |
| chr20:34,312,547–34,313,008 | 245.8 kb | Distal (>10kb) Multiome | 740 | |
| chr20:34,345,865–34,346,371 | 212.6 kb | Distal (>10kb) Multiome | 61 | |
| chr20:34,362,888–34,363,977 | 195.4 kb | Distal (>10kb) Multiome | 858 | |
| chr20:34,515,293–34,516,855 | 43.2 kb | Distal (>10kb) Multiome | 1003 | |
| chr20:34,549,322–34,549,906 | 9.0 kb | Proximal (<10kb) Multiome | 216 | |
| chr20:34,558,287–34,559,412 | 20 bp | At TSS Multiome | 380 | |
| chr20:34,676,509–34,677,593 | 118.3 kb | Distal (>10kb) Multiome | 954 | |
| chr20:34,703,810–34,705,103 | 145.8 kb | Distal (>10kb) Multiome | 903 | |
| chr20:34,708,877–34,710,404 | 151.0 kb | Distal (>10kb) Multiome HiCAR | 576 | |
| chr20:34,824,452–34,825,860 | 266.7 kb | Distal (>10kb) Multiome | 852 |
Genomic view of the MAP1LC3A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.