RBM20

RNA binding motif protein 20

This gene encodes a protein that binds RNA and regulates splicing. Mutations in this gene have been associated with familial dilated cardiomyopathy. [provided by RefSeq, Apr 2014]

Member of: DE-4 DE-4.31 Developmental clusters: GC7

Biological processes 30 terms

RNA binding (GO:0003723)RNA binding (GO:0003723)cytoplasmic ribonucleoprotein granule (GO:0036464)cytoplasmic ribonucleoprotein granule (GO:0036464)heart formation (GO:0060914)heart formation (GO:0060914)heart formation (GO:0060914)mRNA binding (GO:0003729)negative regulation of mRNA splicing, via spliceosome (GO:0048025)negative regulation of mRNA splicing, via spliceosome (GO:0048025)negative regulation of mRNA splicing, via spliceosome (GO:0048025)nucleic acid binding (GO:0003676)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of RNA splicing (GO:0033120)positive regulation of RNA splicing (GO:0033120)pre-mRNA intronic binding (GO:0097157)pre-mRNA intronic binding (GO:0097157)protein binding (GO:0005515)regulation of RNA splicing (GO:0043484)regulation of RNA splicing (GO:0043484)regulation of alternative mRNA splicing, via spliceosome (GO:0000381)regulation of mRNA splicing, via spliceosome (GO:0048024)regulation of mRNA splicing, via spliceosome (GO:0048024)spliceosome-depend formation of circular RNA (GO:0160091)spliceosome-depend formation of circular RNA (GO:0160091)splicing factor binding (GO:1990935)zinc ion binding (GO:0008270)

Expression (TPM)

TFs regulating RBM20 0 TFs

Transcription factors with Perturb-seq knockdown data for RBM20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RBM20

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:110,483,548–110,484,272	160.5 kb	Distal (>10kb) Multiome	273
chr10:110,493,733–110,494,428	150.3 kb	Distal (>10kb) Multiome	112
chr10:110,497,303–110,499,967	146.5 kb	Distal (>10kb) Multiome	772
chr10:110,529,265–110,530,944	114.1 kb	Distal (>10kb) Multiome	543
chr10:110,566,581–110,568,626	76.8 kb	Distal (>10kb) Multiome	1050
chr10:110,610,178–110,611,174	33.8 kb	Distal (>10kb) Multiome	383
chr10:110,636,927–110,637,402	6.9 kb	Proximal (<10kb)	174
chr10:110,637,513–110,637,999	6.3 kb	Proximal (<10kb)	128
chr10:110,641,040–110,641,578	2.8 kb	Proximal (<10kb)	372
chr10:110,643,107–110,643,543	791 bp	At TSS	121
chr10:110,643,641–110,644,831	67 bp	At TSS Multiome	427
chr10:110,671,928–110,672,573	27.9 kb	Distal (>10kb) Multiome	567
chr10:110,701,236–110,702,762	57.6 kb	Distal (>10kb) Multiome	253
chr10:110,833,606–110,834,169	189.4 kb	Distal (>10kb) Multiome	160
chr10:110,857,173–110,858,770	213.3 kb	Distal (>10kb) Multiome	690
chr10:110,871,026–110,872,969	227.5 kb	Distal (>10kb) Multiome	918
chr10:110,918,245–110,920,897	275.0 kb	Distal (>10kb) Multiome	1037

Genome Browser

Genomic view of the RBM20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.