This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for S1PR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = S1PR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of S1PR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:88,799,864–88,800,628 | 190.5 kb | Distal (>10kb) Multiome HiCAR | 169 | |
| chr9:88,957,445–88,958,019 | 33.1 kb | Distal (>10kb) Multiome | 115 | |
| chr9:88,963,044–88,963,643 | 27.4 kb | Distal (>10kb) Multiome | 14 | |
| chr9:88,990,355–88,990,494 | 367 bp | At TSS | 29 | |
| chr9:88,990,709–88,991,952 | 450 bp | At TSS Multiome | 388 | |
| chr9:89,179,706–89,180,739 | 189.5 kb | Distal (>10kb) Multiome | 598 | |
| chr9:89,225,983–89,226,479 | 235.5 kb | Distal (>10kb) Multiome | 72 |
Genomic view of the S1PR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.