The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for CFLAR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CFLAR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CFLAR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:200,863,766–200,865,261 | 251.8 kb | Distal (>10kb) Multiome | 1111 | |
| chr2:200,888,532–200,889,950 | 227.1 kb | Distal (>10kb) Multiome | 1108 | |
| chr2:200,962,915–200,964,242 | 152.8 kb | Distal (>10kb) Multiome | 1021 | |
| chr2:201,071,202–201,072,338 | 44.6 kb | Distal (>10kb) Multiome | 993 | |
| chr2:201,090,426–201,091,071 | 25.6 kb | Distal (>10kb) Multiome | 68 | |
| chr2:201,116,279–201,117,190 | 250 bp | At TSS Multiome | 907 | |
| chr2:201,118,264–201,119,153 | 2.3 kb | Proximal (<10kb) Multiome | 863 | |
| chr2:201,120,046–201,121,105 | 3.2 kb | Proximal (<10kb) | 91 | |
| chr2:201,124,016–201,124,598 | 7.2 kb | Proximal (<10kb) | 387 | |
| chr2:201,125,205–201,126,756 | 10.0 kb | Proximal (<10kb) Multiome | 696 | |
| chr2:201,138,932–201,139,319 | 9.6 kb | Proximal (<10kb) | 7 | |
| chr2:201,139,450–201,139,812 | 9.1 kb | Proximal (<10kb) | 20 | |
| chr2:201,139,950–201,140,164 | 8.8 kb | Proximal (<10kb) | 47 | |
| chr2:201,148,432–201,148,970 | at TSS | At TSS | 63 | |
| chr2:201,157,926–201,158,657 | 42.0 kb | Distal (>10kb) Multiome HiCAR | 540 | |
| chr2:201,182,711–201,183,380 | 66.6 kb | Distal (>10kb) Multiome | 624 |
Genomic view of the CFLAR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.