Enables transcription coactivator activity. Involved in several processes, including intracellular signal transduction; negative regulation of canonical Wnt signaling pathway; and positive regulation of cell differentiation. Located in cytosol and nuclear body. Is active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for WWTR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = WWTR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of WWTR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:149,618,663–149,619,621 | 39.0 kb | Distal (>10kb) Multiome | 241 | |
| chr3:149,656,829–149,659,185 | 48 bp | At TSS Multiome | 974 | |
| chr3:149,661,991–149,662,635 | 4.0 kb | Proximal (<10kb) | 58 | |
| chr3:149,716,922–149,717,701 | 59.3 kb | Distal (>10kb) Multiome | 161 | |
| chr3:149,752,004–149,753,499 | 94.6 kb | Distal (>10kb) Multiome | 991 | |
| chr3:149,812,342–149,813,957 | 155.1 kb | Distal (>10kb) Multiome | 918 |
Genomic view of the WWTR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.