This gene encodes a member of the tumor necrosis factor receptor superfamily. The encoded protein activates nuclear factor kappa-B and mitogen-activated protein kinase 8 (also called c-Jun N-terminal kinase 1), and induces cell apoptosis. Through its death domain, the encoded receptor interacts with tumor necrosis factor receptor type 1-associated death domain (TRADD) protein, which is known to mediate signal transduction of tumor necrosis factor receptors. Knockout studies in mice suggest that this gene plays a role in T-helper cell activation, and may be involved in inflammation and immune regulation. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for TNFRSF21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFRSF21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFRSF21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:46,652,280–46,653,567 | 657.0 kb | Distal (>10kb) Multiome HiCAR | 662 | |
| chr6:47,047,217–47,048,039 | 262.2 kb | Distal (>10kb) Multiome HiCAR | 533 | |
| chr6:47,132,305–47,134,078 | 176.2 kb | Distal (>10kb) Multiome HiCAR | 207 | |
| chr6:47,152,755–47,154,039 | 156.7 kb | Distal (>10kb) Multiome HiCAR | 322 | |
| chr6:47,181,788–47,182,605 | 127.7 kb | Distal (>10kb) Multiome | 96 | |
| chr6:47,221,406–47,222,137 | 88.1 kb | Distal (>10kb) Multiome | 105 | |
| chr6:47,308,643–47,310,418 | 64 bp | At TSS Multiome | 1024 | |
| chr6:47,428,686–47,429,150 | 119.1 kb | Distal (>10kb) Multiome | 105 | |
| chr6:47,477,257–47,478,907 | 167.9 kb | Distal (>10kb) Multiome | 1008 |
Genomic view of the TNFRSF21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.