IGF1R

insulin like growth factor 1 receptor | CD221, IGFIR, IGFR, JTK13, MGC18216

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

Member of: DE-4 DE-4.3 Developmental clusters: GC6

Biological processes 70 terms

ATP binding (GO:0005524)alphav-beta3 integrin-IGF-1-IGF1R complex (GO:0035867)amyloid-beta clearance (GO:0097242)axon (GO:0030424)cell surface receptor protein tyrosine kinase signaling pathway (GO:0007169)cellular response to amyloid-beta (GO:1904646)cellular response to glucose stimulus (GO:0071333)cellular response to oxygen-containing compound (GO:1901701)dendritic spine maintenance (GO:0097062)identical protein binding (GO:0042802)immune response (GO:0006955)insulin binding (GO:0043559)insulin receptor activity (GO:0005009)insulin receptor binding (GO:0005158)insulin receptor complex (GO:0005899)insulin receptor signaling pathway (GO:0008286)insulin receptor signaling pathway (GO:0008286)insulin receptor signaling pathway (GO:0008286)insulin receptor substrate binding (GO:0043560)insulin receptor substrate binding (GO:0043560)insulin-like growth factor I binding (GO:0031994)insulin-like growth factor I binding (GO:0031994)insulin-like growth factor binding (GO:0005520)insulin-like growth factor receptor activity (GO:0005010)insulin-like growth factor receptor activity (GO:0005010)insulin-like growth factor receptor activity (GO:0005010)insulin-like growth factor receptor activity (GO:0005010)insulin-like growth factor receptor signaling pathway (GO:0048009)insulin-like growth factor receptor signaling pathway (GO:0048009)insulin-like growth factor receptor signaling pathway (GO:0048009)insulin-like growth factor receptor signaling pathway (GO:0048009)membrane (GO:0016020)membrane (GO:0016020)negative regulation of MAPK cascade (GO:0043409)negative regulation of apoptotic process (GO:0043066)negative regulation of apoptotic process (GO:0043066)peptidyl-tyrosine autophosphorylation (GO:0038083)phosphatidylinositol 3-kinase binding (GO:0043548)phosphatidylinositol 3-kinase binding (GO:0043548)phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0043491)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)positive regulation of MAPK cascade (GO:0043410)positive regulation of cell migration (GO:0030335)positive regulation of cell population proliferation (GO:0008284)positive regulation of cell population proliferation (GO:0008284)positive regulation of cold-induced thermogenesis (GO:0120162)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction (GO:0051897)positive regulation of protein-containing complex disassembly (GO:0043243)protein autophosphorylation (GO:0046777)protein binding (GO:0005515)protein kinase activity (GO:0004672)protein kinase complex (GO:1902911)protein tyrosine kinase activity (GO:0004713)protein tyrosine kinase activity (GO:0004713)protein tyrosine kinase activity (GO:0004713)protein tyrosine kinase activity (GO:0004713)regulation of JNK cascade (GO:0046328)regulation of JNK cascade (GO:0046328)signal transduction (GO:0007165)signaling receptor complex (GO:0043235)structural molecule activity (GO:0005198)transcytosis (GO:0045056)transmembrane receptor protein tyrosine kinase activity (GO:0004714)

Expression (TPM)

TFs regulating IGF1R 0 TFs

Transcription factors with Perturb-seq knockdown data for IGF1R. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = IGF1R upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to IGF1R

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of IGF1R, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr15:98,420,547–98,422,467	226.8 kb	Distal (>10kb) Multiome	500
chr15:98,428,225–98,428,959	220.0 kb	Distal (>10kb) Multiome	413
chr15:98,501,299–98,502,351	146.7 kb	Distal (>10kb) Multiome HiCAR	144
chr15:98,546,470–98,548,964	99.9 kb	Distal (>10kb) Multiome HiCAR	566
chr15:98,554,298–98,555,962	93.7 kb	Distal (>10kb) Multiome	279
chr15:98,646,857–98,649,430	1.1 kb	Proximal (<10kb) Multiome	915
chr15:98,649,621–98,652,516	3.3 kb	Proximal (<10kb) Multiome	643
chr15:98,800,486–98,801,744	152.2 kb	Distal (>10kb) Multiome	418
chr15:98,823,014–98,823,480	174.7 kb	Distal (>10kb) Multiome	359
chr15:98,852,132–98,853,001	203.9 kb	Distal (>10kb) Multiome HiCAR	587
chr15:99,058,502–99,059,907	410.7 kb	Distal (>10kb) Multiome HiCAR	515

Genome Browser

Genomic view of the IGF1R locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.