Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PLAG1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PLAG1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PLAG1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:55,919,468–55,920,026 | 291.5 kb | Distal (>10kb) Multiome | 374 | |
| chr8:56,073,616–56,075,349 | 136.7 kb | Distal (>10kb) Multiome | 1070 | |
| chr8:56,156,925–56,157,710 | 54.0 kb | Distal (>10kb) Multiome | 251 | |
| chr8:56,202,325–56,202,690 | 8.6 kb | Proximal (<10kb) | 102 | |
| chr8:56,210,270–56,212,762 | 258 bp | At TSS Multiome | 1021 | |
| chr8:56,220,819–56,220,993 | 9.5 kb | Proximal (<10kb) | 42 | |
| chr8:56,447,390–56,448,440 | 236.8 kb | Distal (>10kb) Multiome | 296 |
Genomic view of the PLAG1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.