This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ACKR3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ACKR3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ACKR3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:236,566,024–236,566,321 | 1.5 kb | Proximal (<10kb) | 12 | |
| chr2:236,567,303–236,570,807 | 109 bp | At TSS Multiome | 479 | |
| chr2:236,572,314–236,572,861 | 4.5 kb | Proximal (<10kb) | 94 | |
| chr2:236,573,025–236,573,363 | 5.2 kb | Proximal (<10kb) | 17 | |
| chr2:236,621,646–236,622,261 | 54.1 kb | Distal (>10kb) Multiome | 34 | |
| chr2:236,822,898–236,824,383 | 255.5 kb | Distal (>10kb) Multiome HiCAR | 178 | |
| chr2:236,955,589–236,957,065 | 388.6 kb | Distal (>10kb) Multiome HiCAR | 297 | |
| chr2:237,085,238–237,086,212 | 518.0 kb | Distal (>10kb) Multiome HiCAR | 935 |
Genomic view of the ACKR3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.