Ganglioside GM3 is known to participate in the induction of cell differentiation, modulation of cell proliferation, maintenance of fibroblast morphology, signal transduction, and integrin-mediated cell adhesion. The protein encoded by this gene is a type II membrane protein which catalyzes the formation of GM3 using lactosylceramide as the substrate. The encoded protein is a member of glycosyltransferase family 29 and may be localized to the Golgi apparatus. Mutation in this gene has been associated with Amish infantile epilepsy syndrome. Transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ST3GAL5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ST3GAL5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ST3GAL5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:85,595,068–85,596,226 | 293.4 kb | Distal (>10kb) Multiome | 804 | |
| chr2:85,601,954–85,603,493 | 286.3 kb | Distal (>10kb) Multiome | 852 | |
| chr2:85,611,558–85,612,589 | 277.0 kb | Distal (>10kb) Multiome | 875 | |
| chr2:85,615,831–85,616,609 | 272.9 kb | Distal (>10kb) Multiome | 898 | |
| chr2:85,678,904–85,679,599 | 209.7 kb | Distal (>10kb) Multiome | 445 | |
| chr2:85,753,145–85,755,032 | 135.2 kb | Distal (>10kb) Multiome | 527 | |
| chr2:85,827,451–85,827,914 | 61.4 kb | Distal (>10kb) Multiome | 364 | |
| chr2:85,888,294–85,889,666 | 16 bp | At TSS Multiome | 804 | |
| chr2:85,897,748–85,897,919 | 8.7 kb | Proximal (<10kb) | 10 | |
| chr2:85,921,071–85,922,368 | 32.8 kb | Distal (>10kb) Multiome | 280 | |
| chr2:85,996,436–85,996,920 | 107.7 kb | Distal (>10kb) Multiome HiCAR | 200 | |
| chr2:86,105,431–86,106,679 | 216.9 kb | Distal (>10kb) Multiome | 923 | |
| chr2:86,172,557–86,173,357 | 283.8 kb | Distal (>10kb) Multiome | 74 |
Genomic view of the ST3GAL5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.