This gene belongs to the angiopoietin family of growth factors. The protein encoded by this gene is an antagonist of angiopoietin 1, and both angiopoietin 1 and angiopoietin 2 are ligands for the endothelial TEK receptor tyrosine kinase. Angiopoietin 2 is upregulated in multiple inflammatory diseases and is implicated in the direct control of inflammation-related signaling pathways. The encoded protein affects angiogenesis during embryogenesis and tumorigenesis, disrupts the vascular remodeling ability of angiopoietin 1, and may induce endothelial cell apoptosis. This gene serves a prognostic biomarker for acute respiratory distress syndrome. [provided by RefSeq, Aug 2020]
Transcription factors with Perturb-seq knockdown data for ANGPT2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ANGPT2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ANGPT2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:6,405,668–6,407,592 | 156.9 kb | Distal (>10kb) Multiome | 759 | |
| chr8:6,553,721–6,554,476 | 8.8 kb | Proximal (<10kb) | 42 | |
| chr8:6,554,689–6,555,051 | 8.2 kb | Proximal (<10kb) | 10 | |
| chr8:6,555,493–6,556,153 | 7.1 kb | Proximal (<10kb) | 46 | |
| chr8:6,559,766–6,561,284 | 2.9 kb | Proximal (<10kb) Multiome | 551 | |
| chr8:6,561,929–6,562,343 | 901 bp | At TSS | 79 | |
| chr8:6,562,645–6,563,524 | 139 bp | At TSS Multiome | 199 | |
| chr8:6,570,280–6,570,884 | 7.0 kb | Proximal (<10kb) | 241 | |
| chr8:6,707,768–6,709,358 | 145.0 kb | Distal (>10kb) Multiome HiCAR | 1010 | |
| chr8:6,800,522–6,801,235 | 237.5 kb | Distal (>10kb) Multiome | 483 | |
| chr8:6,834,068–6,835,901 | 272.1 kb | Distal (>10kb) Multiome | 395 | |
| chr8:6,840,478–6,841,374 | 277.5 kb | Distal (>10kb) Multiome | 350 |
Genomic view of the ANGPT2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.