Enables RNA binding activity. Predicted to be involved in several processes, including cellular response to glucose starvation; negative regulation of cytoplasmic translation; and response to ischemia. Located in cytoplasm and nucleus. Biomarker of liver cirrhosis; portal hypertension; and primary biliary cholangitis. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CPEB4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CPEB4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CPEB4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:173,615,977–173,617,113 | 271.6 kb | Distal (>10kb) Multiome HiCAR | 845 | |
| chr5:173,653,855–173,654,363 | 234.3 kb | Distal (>10kb) Multiome | 34 | |
| chr5:173,885,454–173,885,854 | 2.5 kb | Proximal (<10kb) | 195 | |
| chr5:173,887,593–173,889,015 | 228 bp | At TSS Multiome | 862 | |
| chr5:173,917,847–173,918,288 | at TSS | At TSS | 383 | |
| chr5:173,972,772–173,973,892 | 85.0 kb | Distal (>10kb) Multiome | 508 |
Genomic view of the CPEB4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.